Search results for "genetics [Cerebellar Neoplasms]"
showing 10 items of 3028 documents
Overview and Update on Extracellular Vesicles: Considerations on Exosomes and their Application in Modern Medicine
2022
In recent years, there has been a rapid growth in the knowledge of cell-secreted extracellular vesicle functions. They are membrane enclosed and loaded with proteins, nucleic acids, lipids, and other biomolecules. After being released into the extracellular environment, some of these vesicles are delivered to recipient cells; consequently, the target cell may undergo physiological or pathological changes. Thus, extracellular vesicles as biological nano-carriers, have a pivotal role in facilitating long-distance intercellular communication. Understanding the mechanisms that mediate this communication process is important not only for basic science but also in medicine. Indeed, extracellular …
Effects of exposure to a glyphosate-based herbicide on haematological parameters, plasma biochemical indices and the microstructure of selected organ…
2022
Contamination of water environments with herbicides is a common problem nowadays. The aim of the current study was to evaluate the effects of Roundup on common carp ( Cyprinus carpio) after 1, 3 and 10 days of exposure. The used concentrations corresponded to 1 and 5 mg/l of the active ingredient (glyphosate potassium salt). The haematological analysis performed showed a decrease of the RBC count, as well as an increase of the other erythrocyte indices (Hb, MCV, MCH, MCHC). Most of these changes were dependent on the concentration and time. An increase of the WBC count and the percentage of immature neutrophils occurred, thus indicating the presence of inflammation. In the studied blood bio…
Recovery from Food Waste-Biscuit Doughs Enriched with Pomegranate Peel Powder as a Model of Fortified Aliment
2022
This research was funded by the "IEV Programme de Cooperation Italie-Tunisie 2014-2020, Re-lancer une nouvelle economie (Re-Ne)". EU project code C-5-3.1-39.
Muscular Strength Imbalances Are not Associated with Skin Temperature Asymmetries in Soccer Players
2020
Although strength imbalances using isokinetic dynamometer have been examined for injury risk screening in soccer players, it is very expensive and time-consuming, making the evaluation of new methods appealing. The aim of the study was to analyze the agreement between muscular strength imbalances and skin temperature bilateral asymmetries as well as skin temperature differences in the hamstrings and quadriceps. The skin temperature of the anterior and posterior thigh of 59 healthy male soccer athletes was assessed at baseline using infrared thermography for the identification of hamstrings-quadriceps skin temperature differences and thermal asymmetries (>
Evolutionary game theory of continuous traits from a causal perspective
2023
Modern evolutionary game theory typically deals with the evolution of continuous, quantitative traits under weak selection, allowing the incorporation of rich biological detail and complicated nonlinear interactions. While these models are commonly used to find candidates for evolutionary endpoints and to approximate evolutionary trajectories, a less appreciated property is their potential to expose and clarify the causal structure of evolutionary processes. The mathematical step of differentiation breaks a nonlinear model into additive components which are more intuitive to interpret, and when combined with a proper causal hypothesis, partial derivatives in such models have a causal meanin…
Regulatory cytokine gene polymorphisms and risk of colorectal carcinoma.
2006
It is well established that cancer arises in chronically inflamed tissue, and this is particularly notable in the gastrointestinal tract. Classic examples include Helicobacter pylori-associated gastric cancer, hepatocellular carcinoma, and inflammatory bowel disease-associated colorectal cancer. Growing evidence suggests that these associations might be not casual findings. Focusing on individual cytokines has generated evidence that anti-inflammatory cytokine interleukin (IL)-10 and transforming growth factor-beta1 (TGF-beta1) may have a complex role in gastrointestinal carcinogenesis. As an example, IL-10-deficient mice develop severe atrophic gastritis and a chronic enterocolitis, develo…
The closure of Pak1-dependent macropinosomes requires the phosphorylation of CtBP1/BARS
2007
Membrane fission is an essential process in membrane trafficking and other cellular functions. While many fissioning and trafficking steps are mediated by the large GTPase dynamin, some fission events are dynamin independent and involve C-terminal-binding protein-1/brefeldinA-ADP ribosylated substrate (CtBP1/BARS). To gain an insight into the molecular mechanisms of CtBP1/BARS in fission, we have studied the role of this protein in macropinocytosis, a dynamin-independent endocytic pathway that can be synchronously activated by growth factors. Here, we show that upon activation of the epidermal growth factor receptor, CtBP1/BARS is (a) translocated to the macropinocytic cup and its surroundi…
Nonlinear nystagmus processing causes torsional VOR nonlinearity.
2003
The eye movement component that rotates around the line of sight, i.e., the ocular torsion, is in many aspects different from horizontal and vertical eye movements. While ocular torsion is mediated only by reflexive pathways like the torsional vestibulo-ocular and optokinetic reflexes (TVOR and OKN, respectively), horizontal and vertical components are also subject to intentional control mechanisms that are mediated by the saccadic and the pursuit systems. Dynamic properties of torsional eye movements are also very distinct. While horizontal and vertical VOR components show a gain close to unity and a small neural integration leakage with a time constant around pi=30 s, the TVOR shows a sma…
Lipid nutrition and eye health
2010
Revue non indexée dans le JCR.; International audience; According to demographic forecasts, the elderly population will represent a growing part of the developed societies in the near future. Eye diseases are the second most prevalent pathologies after the age of 65 years. Age-related macular degeneration (AMD) is the leading cause of irreversible vision loss in western countries. The number of people suffering from ocular pathologies is expected to increase sharply in the near future, becoming a socio-economic burden. Recent data indicate that lipid nutrients may represent new tools in the prevention of eye diseases, and especially AMD.